{ "_id": "6a1f0d20b401979e7341cfa0", "Package": "multiDEGGs", "Title": "Multi-Omic Differentially Expressed Gene-Gene Pairs", "Version": "1.2.1.9000", "Authors@R": "c(person(given = \"Elisabetta\",\nfamily = \"Sciacca\",\nrole = c(\"aut\", \"cre\", \"cph\"),\nemail = \"e.sciacca@qmul.ac.uk\",\ncomment = c(ORCID = \"0000-0001-7525-1558\")),\nperson(given = \"Myles\",family = \"Lewis\",\nrole = c(\"ctb\"),\nemail = \"myles.lewis@qmul.ac.uk\",\ncomment = c(ORCID = \"0000-0001-9365-5345\")))", "Maintainer": "Elisabetta Sciacca ", "Description": "Performs multi-omic differential network analysis by\nrevealing differential interactions between molecular entities\n(genes, proteins, transcription factors, or other biomolecules)\nacross the omic datasets provided. For each omic dataset, a\ndifferential network is constructed where links represent\nstatistically significant differential interactions between\nentities. These networks are then integrated into a\ncomprehensive visualization using distinct colors to\ndistinguish interactions from different omic layers. This\nunified display allows interactive exploration of cross-omic\npatterns, such as differential interactions present at both\ntranscript and protein levels. For each link, users can access\ndifferential statistical significance metrics (p values or\nadjusted p values, calculated via robust or traditional linear\nregression with interaction term) and differential regression\nplots. The methods implemented in this package are described in\nSciacca et al. (2023) .", "License": "GPL-3", "Encoding": "UTF-8", "LazyData": "true", "LazyDataCompression": "gzip", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.3", "Language": "en-gb", "URL": "https://github.com/elisabettasciacca/multiDEGGs/,\nhttps://elisabettasciacca.github.io/multiDEGGs/", "BugReports": "https://github.com/elisabettasciacca/multiDEGGs/issues", "VignetteBuilder": "knitr", "Config/testthat/edition": "3", "Config/pak/sysreqs": "cmake make libuv1-dev zlib1g-dev", "Repository": "https://elisabettasciacca.r-universe.dev", "Date/Publication": "2026-04-17 10:07:02 UTC", "RemoteUrl": "https://github.com/elisabettasciacca/multideggs", "RemoteRef": "HEAD", "RemoteSha": "722313aa5519aead78268a7b646788db2fcfacea", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-17 09:17:34 UTC", "User": "root" }, "Author": "Elisabetta Sciacca [aut, cre, cph] (ORCID:\n),\nMyles Lewis [ctb] (ORCID: )", "MD5sum": "0f2ea2c074b4251b231f175192026969", "_user": "elisabettasciacca", "_type": 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